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Korean J Asthma Allergy Clin Immunol. 2010 Dec;30(4):285-292. Korean. Original Article.
Kang MK , Kim BK , Kang SY , Kim MY , Lee SY , Kim TW , Lee SH , Kim SH , Kang HR , Chang YS , Kim SS , Cho SH , Min KU , Park HW .
Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea. guineapark@yahoo.com
Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Center, Seoul, Korea.
Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
Abstract

BACKGROUND: The Kimura disease, a chronic inflammatory disorder of unknown etiology, is characterized by subcutaneous mass, regional lymphadenopathy, peripheral blood eosinophilia or increased serum immunoglobulin E level. So far, there has been limited information concerning this disease. OBJECTIVE: To investigate clinical features of Kimura disease in Korea. METHOD: We retrospectively reviewed 33 patients who had a histologically proven Kimura disease from January 1995 to March 2010 at Hospital. Then clinical features and treatment outcomes were evaluated. RESULT: Of all patients, 28 were male (84.8%), and mean age was 25.2+/-15.1 years. Involved sites were as follows; preauricular (n=8), upper arm (n=8), retroauricular (n=6), submandibular (n=4), eyelid (n=4), inguinal (n=4), and cervical area (n=4). Peripheral blood eosinophilia was observed in 87.1% of patients. Twenty-seven patients were treated by operation, corticosteroids, or radiation, and the other 6 were just followed without any intervention. Among the 27 patients treated, only 12 have achieved a state of control. Treatment outcomes in terms of size and mass numbers were variable. CONCLUSION: Kimura disease should be ruled out in young male who shows painless soft tissue swellings with peripheral blood eosinophilia in Korea. The optimal management for Kimura disease needs to be investigated further.

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