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Korean J Asthma Allergy Clin Immunol. 2010 Mar;30(1):55-58. Korean. Case Report.
Lee SH , Jung HS , Yoon TY , Chang EJ , Kim MK , Kim KS .
Department of Internal Medicine, Medical Research Institute, College of Medicine, Chungbuk National University, Cheongju, Korea.
Department of Dermatology, Medical Research Institute, College of Medicine, Chungbuk National University, Cheongju, Korea.
Chungbuk Regional Pharmacovigilence Center, Cheongju, Korea.
Abstract

Antihistamine is one of the most widely used medications for allergic rhinitis, urticaria and other allergic conditions. However, the prevalence of adverse skin reactions induced by antihistamines are quite low because they can mask the skin lesions. A 43-year-old man experienced generalized urticaria, angioedema, wheezing, dyspnea and hypotension after taking Minoltrochy composed of cetylpyridium and chlorpheniramine for common cold. Skin prick tests with the extracts of cetylpyridium and chlorpheniramine showed a weak positive reaction to chlorpheniramine. Oral challenge tests showed a positive reaction to chlorpheniramine but not to cetylpyridium. Aspirin-intolerant asthma was confirmed by the aspirin oral challenge test. With these results, we confirmed the case of drug allergy to chlorpheniramine in a patient with aspirin-intolerant asthma.

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