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Korean J Asthma Allergy Clin Immunol. 2007 Sep;27(3):157-161. Korean. Original Article.
Kim SS , Park CH , Park MJ , Choi SH , Kim YS , Park HW , Chang YS , Shin CS , Oh BH , Min KU , Kim YY , Cho SH .
Healthcare System GangNam Center, Seoul National University Hospital, Korea.
Healthcare Research Institute Seoul, Seoul National University Hospital, Korea.
Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.

BACKGROUND: Adverse reactions to radio-contrast media (CM) represent a serious problem. There have been few reports about incidence of adverse reactions to CM in general population. OBJECTIVE: The purpose of this study was to evaluate the incidence and clinical features of adverse reactions to low osmolar, nonionic contrast media in the general population. METHOD: A total of 12,177 examinee underwent contrast-enhanced CT using low osmolar, nonionic CM. Immediate adverse reaction is defined as symptoms occur within 1 hour after contrast administration and late adverse reaction is defined as symptoms occur more than 1 hour but less than 7 days following contrast administration. A questio-nnaire was used to collect general and medical information. RESULT: Adverse events were noted in 306 cases of total 13,552 cases. The incidence of adverse reactions was 2.3% and severe reactions was 0.04%. The incidence of immediate reaction was 2.0% and late reactions was 0.3%. Symptoms of immediate and late reactions were nausea/vomiting (22.2%), erythema/pruritus/urticaria (74.2%), angioedema (2.0%) and hypotension (1.6%). CONCLUSION: The incidence of adverse reaction to low osmolar, nonionic CM was 2.3% in the general population. The skin was the most commonly affected site of adverse reactions.

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