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Korean J Asthma Allergy Clin Immunol. 2005 Dec;25(4):305-312. English. Original Article.
Lim SJ , Ha KH , Yoon JS , Lee MH , Kim HH , Han JW , Lee JS .
Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea. jslee@catholic.ac.kr
Abstract

BACKGROUND: RSV induces the production of cytokines and chemokines in airway epithelial cells. Corticosteroids (CSs) can inhibit the production. OBJECTIVE: We examined whether the inhibitory effect of CSs on cytokines and chemokines production in airway epithelial cells infected with RSV varies according to both the kinds of CSs and and to the timing of CSs treatment. METHOD: As the CSs pretreatment group, BEAS-2B cells were pretreated with budesonide (BUD), fluticasone propionate (FP), or methylprednisolone (MP), and then the cells were infected with RSV. As the CSs post-treatment group, BEAS-2B cells were infected with RSV. The cells were next treated with CSs. Interleukin (IL)-6, IL-8, and RANTES (regulated on activation, normal T cell expressed and secreted) levels in each of the collected supernatan were determined. RESULT: In the CSs pretreatment group, the strength of the inhibitory effect was in the order of MP>FP>BUD on IL-6 production. Regarding the inhibitory effect on IL-8 or RANTES production, no significant difference was detected. In the CSs post-treatment group, the strength of the inhibitory effect was in the order of MP>BUD>FP on the production of IL-6. MP=FP >BUD on IL-8 production. BUD>FP=MP on RANTES production. CONCLUSION: The inhibitory effects of CSs on the production of IL-6, IL-8, and RANTES in BEAS-2B cells infected with RSV varies widely according to the kinds of cytokines, the kinds of CSs and the timing of the CSs treatment.

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