The diagnosis of congenital heart disease includes rare and diverse disorders. Children with congenital heart disease represent a growing population: The incidence of congenital heart defects is almost 1 in 100 live births, and of these, approximately 23 of 1000 newborns will require invasive treatment or will die as a consequence of their diagnosis by 1 year of age. Because of improved interventions, >1 million adults are now living with congenital heart disease. Selected congenital heart defects (or the process of their repair) lead to an increased risk for adult cardiovascular disease compared with the general population. Now we reviewed the methods of assessment for differential diagnosis of congenital heart diseases.