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Ultrasonography. 2017 Jul;36(3):171-184. English. Review. https://doi.org/10.14366/usg.17021
Mullick Chowdhury S , Lee T , Willmann JK .
Department of Radiology, Stanford University School of Medicine, Stanford, CA, USA. willmann@stanford.edu
Abstract

Recent advancements in ultrasound and microbubble (USMB) mediated drug delivery technology has shown that this approach can improve spatially confined delivery of drugs and genes to target tissues while reducing systemic dose and toxicity. The mechanism behind enhanced delivery of therapeutics is sonoporation, the formation of openings in the vasculature, induced by ultrasound-triggered oscillations and destruction of microbubbles. In this review, progress and challenges of USMB mediated drug delivery are summarized, with special focus on cancer therapy.

Copyright © 2019. Korean Association of Medical Journal Editors.