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J Korean Neurol Assoc. 2019 May;37(2):161-165. Korean. Original Article. https://doi.org/10.17340/jkna.2019.2.7
Hyun JW , Kim S , Shin HS , Yun JY , Kim SY , Kim SH , Kim JK , Jeong JH , Yoo H , Gwak HS , Kim HJ .
Department of Neurology, National Cancer Center, Goyang, Korea. hojinkim@ncc.re.kr
Department of Neurology, Ewha Womans University School of Medicine, Seoul, Korea.
Department of Family Medicine, Kyung Hee University Medical Center, Seoul, Korea.
Department of Laboratory Medicine, National Cancer Center, Goyang, Korea.
Department of Laboratory Medicine, National Medical Center, Seoul, Korea.
Peripheral Neuropathy Research Center and Department of Neurology, Dong-A University College of Medicine, Busan, Korea.
Neuro-Oncoloy Clinic, National Cancer Center, Goyang, Korea.
Abstract

Background

The early and accurate diagnosis of leptomeningeal metastasis (LM) has become important because of introduction of new therapeutic strategies for LM and increasing incidence of LM along with longer survival of cancer patients. We aimed to evaluate the role of cerebrospinal fluid (CSF) CYFRA 21-1 as a diagnostic indicator for LM in patients with cancer.

Methods

CSF CYFRA 21-1 level was analyzed using electro-chemiluminescent immunoassay. The difference in concentration of CSF CYFRA 21-1 between 91 patients with LM and 339 control groups (patients with other neurological disease or healthy controls) was investigated. The cut-off value of CSF CYFRA 21-1 as a diagnostic indicator for LM and its diagnostic performance were evaluated.

Results

The CSF CYFRA 21-1 was significantly higher in LM patients than control groups (p<0.001). A cut-off value of diagnosis for LM in patients with cancer was 1.59 ng/mL. The sensitivity, specificity, accuracy, and positive and negative predictive values of CSF CYFRA 21-1 were 80.2%, 96.2%, 92.8%, 84.9%, 94.8% for diagnosis of LM.

Conclusions

These results suggested that CSF CYFRA 21-1 can be an additional diagnostic indicator for cancer patients with LM.

Copyright © 2019. Korean Association of Medical Journal Editors.