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J Korean Neurol Assoc. 2018 May;36(2):81-85. Korean. Original Article.
Lee MK , Song JS .
Department of Neurology, Gangneung Asan Hospital, University of Ulsan College of Medicine, Gangneung, Korea.
aDepartment of Preventive Medicine, College of Medicine, Catholic Kwandong University, Gangneung, Korea.


The relationship between hypertension and the lesion distribution of posterior reversible encephalopathy syndrome (PRES) is in debate.


Twenty patients with PRES which developed during chemotherapy or immunosuppression treatment for the control of underlying malignancy or auto-immune disorders were selected from the database. Data regarding brain images, clinical symptoms, co-morbid illnesses, and mean arterial pressure (MAP) at the pre-symptomatic period (one day before the symptom onset) and at the symptom onset were collected. Patients were divided into two groups according to the presence of pre-symptomatic hypertension. The lesion distribution degree was calculated by numerical method (involvement score [IS]) and compared with MAP.


No significant differences of clinical symptoms were found between two groups. IS and onset period MAP were higher in the hypertensive group. Pre-symptomatic MAP correlated with onset period MAP and IS in total patients. No significant correlation was found between IS and onset period MAP.


The PRES patient with hypertension in the pre-symptomatic period would show more spatially distributed brain lesions than the patient with stable blood pressure.

Copyright © 2019. Korean Association of Medical Journal Editors.