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J Korean Neurol Assoc. 2012 Aug;30(3):159-169. Korean. Review.
Han SW , Kim HY , Park JM , Koo J , Cho YJ , Kang K , Yu KH , Rha JH , Heo JH , Kwon SU , Oh CW , Bae HJ , Lee BC , Yoon BW , Chung CS , Hong KS .
Department of Neurology, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Korea.
Department of Neurology, Konkuk University College of Medicine, Seoul, Korea.
Department of Neurology, Eulji University College of Medicine, Seoul, Korea.
Department of Neurology, Catholic University College of Medicine, Seoul, Korea.
Department of Neurology, Ilsan Paik Hospital, Inje University College of Medicine, Ilsan, Korea. nrhks@paik.ac.kr
Department of Neurology, Hallym University College of Medicine, Anyang, Korea.
Department of Neurology, Inha University College of Medicine, Incheon, Korea.
Department of Neurology, Yonsei University College of Medicine, Seoul, Korea.
Department of Neurology, University of Ulsan College of Medicine, Seoul, Korea.
Department of Neurosurgery, Seoul National University College of Medicine, Seoul, Korea.
Department of Neurology, Seoul National University College of Medicine, Seoul, Korea.
Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Abstract

BACKGROUND: This scientific statement is intended to provide a systematic review of new evidences in dyslipidemia and inflammation for primary stroke prevention. METHODS: Using a structured literature search, we identified major observational studies, clinical trials, meta-analyses, and updated major guidelines published between July 2007 and November 2010. In addition to the brief summary of earlier evidences employed in the first edition of Korean clinical practice guideline for primary prevention of stroke, we summarized the newly identified evidences. RESULTS: For dyslipidemia, observational studies further support a strong association between ischemic stroke and high total and low-density lipoprotein cholesterol and low high-density lipoprotein cholesterol. Two clinical trials and 6 meta-analyses confirm statin efficacy for primary prevention of stroke in high risk patients. Efficacy of other lipid-lowering agents is not established. For inflammation, inflammatory markers might help to identify patients having high risk for stroke or cardiovascular event and to decide whether statin therapy is indicated, but its usefulness for broad population needs to be confirmed. CONCLUSIONS: Writing committee will continue to keep an eye on upcoming evidences to timely update the guideline for primary stroke prevention in dyslipidemia and inflammation.

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