Facial grimacing can be a manifestation of complex partial seizures from the temporal lobe. We observed a case of seizure with facial grimacing and partial loss of consciousness during an electroencephalography recording. The recording revealed interictal spikes on the left-sided inferior temporal electrodes and ictal discharges starting on the same electrodes. The current source appeared to be in the inferior and lateral temporal areas of the left cerebral hemisphere. These results show that it is possible to localize the current sources responsible for interictal spikes.