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J Korean Neurol Assoc. 2008 Nov;26(4):376-378. Korean. Case Report.
Shin HE , Kim JG , Jo SR , Jeong SH , Yoon SJ .
Department of Neurology, Eulji University School of Medicine, Daejeon, Korea. trumind@lycos.co.kr
Abstract

Marchiafava-Bignami disease (MBD) is characterized by cerebral white matter lesions associated with chronic alcoholism. Premortem diagnosis of MBD is usually based on history and clinical manifestations. We report a case of acute MBD in which diffusion-weighted MRI (DWI) showed high signal intensities along the white matter including the corpus callosum. DWI may be useful in premortem diagnosis of acute MBD.

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