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J Korean Neurol Assoc. 2006 Dec;24(6):585-588. Korean. Case Report.
Kim SG , Kwon SB , Kwon KH , Jung S , Hwang SH .
Department of Neurology, Hallym University College of Medicine, Seoul, Korea.

Neuromyotonia, or Isaacs' syndrome, consists of continuous muscle fiber activity caused by hyperexcitability of the peripheral nerves. Rarely, these patients also develop CNS symptoms characterized by confusion, insomnia, hallucinations, and agitation. A rare disease consisting of neuromyotonia, autonomic symptoms, and CNS dysfunction is called Morvan's syndrome. We report a 24-year-old man who presented with insomnia, malaise, anorexia, hyperhidrosis, palpitation and myokymia in both the lower extremities. The pathomechanism of Morvan's syndrome is related to the voltage-gated K+ channel (VGKC) antibodies.

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