We report two cases of Wernicke encephalopathy presenting with convulsive seizures. The first patient had been supplied with total parenteral nutrition due to acute pancreatitis and presented with partial seizure evolving to generalized seizure. The second patient had been malnourished due to alcoholism and recent dyspepsia after a gastrectomy, who presented with generalized seizure. Brain MRI revealed high-signal lesions in the focal cerebral cortex on T2-weighted, FLAIR, and diffusion-weighted images. After a thiamine injection, the patients recovered and abnormalities on the MRIs disappeared.