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J Korean Neurol Assoc. 1995 Sep;13(3):696-702. Korean. Original Article.
Kim SY , La DL , Park SH , Koo HS , Chi JG .
Department of Neurology, College of Medicine, Hallym University, Korea.
Department of Neurology, Samsung Medical Center, Korea.
Department of Neurology, Boramae City Hospital, Korea.
Dept of Pathology, College of Medicine, Ewha women's University, Korea.
Dept of Pathology, College of Medicine, Seoul National University, Korea.
Abstract

A patient presenting with the characteristic clinical features of the dementia of Pick's type is described, in whom neuropathological examination of brain biopsy material revealed atypical features, including extensive subcotical gliosis with mild cortical neuronal loss and without any neuronal cytoskeletal inclusions (Pick bodies, neurofibrillary tangles, and Lewy bodies) and amyloid deposits (senile plaques). And she has the suggestive family history of the same clinical features in her two brothers. So, the clinical and pathological features are discussed with particular reference to typical Alzheimer's disease and Pick's disease, and it is proposed that the case should be classified as familial progressive subcortical gliosis.

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