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J Korean Neurol Assoc. 1995 Jun;13(2):390-396. Korean. Brief Communication.
Kim KS , Yoo KM , Kim JK .
Department of Neurology, General Surgery Kosin Medeical College, Korea.

Stiff-man syndrome is a rare disorder characterized by intermittent spasms and stiffness of the axial and limb muscles, associated with an electromyographic pattern of continuous motor unit activity in affected muscles. The cause of this disorder is unknown, but it has been associated with autoimmune disease and with endocrine disorder. We present a 49 year old female patient with clinical and electrophysiologic features of stiff-man syndrome and postoperative panhypopituitarism, whose muscle stiffness and spasm resolved with diazepam, clonazepam and prednisolonereplacement therapy.

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