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J Korean Neurol Assoc. 1995 Jun;13(2):362-366. Korean. Case Report.
Ham DS , Chang SH , Youn YC , Kim WJ , Kwon OS , Park HM , Kim DE , Lee KW .
Department of Neurology, College of Medicine, Chungang University, Korea.
Department of Obstetrics & Gynecology, College of Medicine, Chungang University, Korea.
Department of Neurology, Seoul National University, College of Medicine, Korea.

Myasthenia gravis (MG) is regarded as autoimmune disorder of neuromuscular transmission and apparently is due to formation of humoral antibody that cross-link to acetylcholine receptor at skeletal muscle end plate. Patients with autoimmune diseases often have circulating antibodies to a variety of different autoantigens and show a variety of manifestations of autoimmune diseases in more than one organ. Therefore, MG patients frequently have manifestations of autoimmune diseases such as thyroid disease, rheumatoid arthritis and systemic lupus erythematosus. But MG in association with premature ovarian failure (POF) rarely has been described. A case of MG with POF and thyroid autoantibodies was experienced and presented with a brief review of literature.

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