Datura stramonium is an annual herb, growing wild in the most part of our country. All parts of the plant contain belladonna alkaloid. Ingestion of Datura stramonium and the resulting toxic symptoms have been already reported throughout the world, but not in Korea. Two cases of acute anticholinergic symptom due to Datura stramonium intoxication are presented. The diagnosis in the first case was suspected on the basis of clinical signs and symptoms, comfirmed by the appearance of similar symptoms and signs in the second, history of ingestion of small amount of stramonium liquor and identification of the plant specimen obtained. Both recovered spontaneously without neurologic sequalae.