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J Korean Neurol Assoc. 1986 Dec;4(2):231-234. Korean. Case Report.
Chang DI , Kim JH , Kim MH .
Department of Neurology, College of Medicine, Hanyang University.

Chymopapain was discovered by Jensen in 1941, and in 1963 Smith demonstrated the chondrolytic properties of chymopapain. Since then, many patients have been injected with this agent. Although there are evidences of neurotoxicity to chymopapain in animals, adverse effects in humans have rarely been reported. We present a case delayed onset of paraplegia after chymopapain chemonucleolysis and review the neurotoxicities to chymopapain.

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