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J Korean Soc Radiol. 2018 Jul;79(1):18-26. English. Original Article.
Jung N , Kim WH .
Department of Radiology, School of Medicine, Kyungpook National University, Kyungpook National University Chilgok Hospital, Daegu, Korea.


To evaluate the association of volumetric breast density with clinicopathological factors in breast cancer patients.

Materials and Methods

A total of 205 Korean patients with breast cancer who underwent mammography for initial staging between January 2015 and June 2016 were enrolled. Volumetric breast density was measured using a fully automated commercial method (Volpara®). in the contralateral breast. The association of volumetric breast density with clinical and histopathological factors was evaluated using t-test and analysis of variance as appropriate.


Mean volumetric breast density in all patients was 13.5% (range, 4.1–34.9%). The mean volumetric breast density in patients with symptom-detected cancers was significantly higher than that in those with screening-detected cancers (14.9% vs. 11.8%, p = 0.002). Mean volumetric breast density tended to decrease with age (20–39 years: 19.0%, 40–59 years: 14.3%, 60–80 years: 7.7%). The mean volumetric breast density in postmenopausal women was significantly lower than that in premenopausal women (9.8% vs. 17.6%, p < .001). Other histopathological factors including histologic grade or hormone receptor status were not associated with volumetric breast density.


Our results suggest that volumetric breast density is associated with the method of detection, age, and menopausal status.

Copyright © 2019. Korean Association of Medical Journal Editors.