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Clin Mol Hepatol. 2014 Dec;20(4):406-410. English. Case Report. https://doi.org/10.3350/cmh.2014.20.4.406
Nayyar M , Imagawa DK , Tirkes T , Demirjian AN , Houshyar R , Sandrasegaran K , Nangia CS , Seery T , Bhargava P , Choi JI , Lall C .
Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
University of California, Irvine, Orange, CA, USA. clall@uci.edu
Indiana University, Indianapolis, IN, USA.
University of Washington, Seattle, WA, USA.
Department of Radiology, College of Medicine, Seoul St.Mary's Hospital, the Catholic University of Korea, Seoul, Korea.
Abstract

Bi-phenotypic neoplasm refers to tumors derived from a common cancer stem cell with unique capability to differentiate histologically into two distinct tumor types. Bi-phenotypic hepatocellular carcinoma-cholangiocarcinoma (HCC-CC), although a rare tumor, is important for clinicians to recognize, since treatment options targeting both elements of the tumor are crucial. Imaging findings of bi-phenotypic HCC-CC are not specific and include features of both HCC and CC. A combination of imaging and immuno-histochemical analysis is usually needed to make the diagnosis.

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