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Clin Mol Hepatol. 2014 Dec;20(4):406-410. English. Case Report.
Nayyar M , Imagawa DK , Tirkes T , Demirjian AN , Houshyar R , Sandrasegaran K , Nangia CS , Seery T , Bhargava P , Choi JI , Lall C .
Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
University of California, Irvine, Orange, CA, USA.
Indiana University, Indianapolis, IN, USA.
University of Washington, Seattle, WA, USA.
Department of Radiology, College of Medicine, Seoul St.Mary's Hospital, the Catholic University of Korea, Seoul, Korea.

Bi-phenotypic neoplasm refers to tumors derived from a common cancer stem cell with unique capability to differentiate histologically into two distinct tumor types. Bi-phenotypic hepatocellular carcinoma-cholangiocarcinoma (HCC-CC), although a rare tumor, is important for clinicians to recognize, since treatment options targeting both elements of the tumor are crucial. Imaging findings of bi-phenotypic HCC-CC are not specific and include features of both HCC and CC. A combination of imaging and immuno-histochemical analysis is usually needed to make the diagnosis.

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