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Diabetes Metab J. 2017 Dec;41(6):486-491. English. Original Article. https://doi.org/10.4093/dmj.2017.41.6.486
Yang SH , Kim C , An HS , An H , Lee JS .
Department of Obstetrics and Gynecology, Ilsin Christian Hospital, Busan, Korea.
Department of Radiological Science, College of Health Sciences, Catholic University of Pusan, Busan, Korea.
Department of Radiology, Inje University Busan Paik Hospital, Inje University College of Medicine, Busan, Korea.
Department of Radiology, Inje University Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea. 033941@paik.ac.kr
Abstract

Background

This study was performed to verify the correlation between abdominal subcutaneous fat thickness (ASFT) measured by ultrasonography (US) during the first trimester of pregnancy and gestational diabetes mellitus (GDM) of the second trimester in Korean women and to establish a standard of ASFT for predicting GDM.

Methods

A total of 333 singleton pregnant women participated in this study. Their ASFT was measured by US during the 10⁺⁶ to 13⁺⁶ weeks of pregnancy; then a GDM confirmatory test (100 g oral glucose tolerance test) was conducted during the 24 to 28 week period of pregnancy. Based on the GDM tests, comparative analyses of the ages of the subjects, pre-pregnancy body mass index (BMI), and weight gain during pregnancy were conducted.

Results

The ages of the subjects and weight gains during pregnancy were not correlated to the GDM of the second trimester of pregnancy, but the pre-pregnancy BMIs (22±3.3 kg/m²) and the ASFT (1.9±0.5 cm) measurements between the control group and subjects during the first trimester of pregnancy were found to show significant differences (P < 0.001). The cut-off value of the ASFT for predicting GDM was determined to be 2.4 cm (area under the curve=0.90, sensitivity 75.61%, specificity 91.78%, P < 0.001). The odds ratio was 2.91 (95% confidence interval, 1.07 to 7.92; P=0.034), which was higher than the 2.4 cm ASFT.

Conclusion

It was determined that ASFT as measured by US during the first trimester of pregnancy can be used to predict the risk of developing GDM during the second trimester of pregnancy and for prognosis.

Copyright © 2019. Korean Association of Medical Journal Editors.