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Diabetes Metab J. 2017 Dec;41(6):466-473. English. Original Article. https://doi.org/10.4093/dmj.2017.41.6.466
Pérez-Matos MC , Morales-Álvarez MC , Toloza FJ , Ricardo-Silgado ML , Mantilla-Rivas JO , Pinzón-Cortes JA , Perez-Mayorga M , Jiménez E , Guevara E , Mendivil CO .
Department of Medicine, Universidad de los Andes School of Medicine, Bogotá, Colombia. cmendivi@uniandes.edu.co
Molecular Epidemiology of Endocrine Diseases Group, Universidad Militar Nueva Granada, School of Medicine, Bogotá, Colombia.
Department of Chemistry, Universidad de los Andes, Bogotá, Colombia.
Section of Endocrinology, Fundación Santa Fe de Bogotá, Bogotá, Colombia.
Abstract

Background

Plasma concentrations of some lysophospholipids correlate with metabolic alterations in humans, but their potential as biomarkers of insulin resistance (IR) is insufficiently known. We aimed to explore the association between plasma linoleoylglycerophosphocholine (LGPC) and objective measures of IR in adults with different metabolic profiles.

Methods

We studied 62 men and women, ages 30 to 69 years, (29% normal weight, 59% overweight, 12% obese). Participants underwent a 5-point oral glucose tolerance test (5p-OGTT) from which we calculated multiple indices of IR and insulin secretion. Fifteen participants additionally underwent a hyperinsulinemic-euglycemic clamp for estimation of insulin-stimulated glucose disposal. Plasma LGPC was determined using high performance liquid chromatography/time-of-flight mass spectrometry. Plasma LGPC was compared across quartiles defined by the IR indices.

Results

Mean LGPC was 15.4±7.6 ng/mL in women and 14.1±7.3 ng/mL in men. LGPC did not correlate with body mass in-dex, percent body fat, waist circumference, blood pressure, glycosylated hemoglobin, log-triglycerides, or high density lipoprotein cholesterol. Plasma LGPC concentrations was not systematically associated with any of the studied 5p-OGTT-derived IR indices. However, LGPC exhibited a significant negative correlation with glucose disposal in the clamp (Spearman r=−0.56, P=0.029). Despite not being diabetic, participants with higher plasma LGPC exhibited significantly higher post-challenge plasma glucose excursions in the 5p-OGTT (P trend=0.021 for the increase in glucose area under the curve across quartiles of plasma LGPC).

Conclusion

In our sample of Latino adults without known diabetes, LGPC showed potential as a biomarker of IR and impaired glucose metabolism.

Copyright © 2019. Korean Association of Medical Journal Editors.