BACKGROUND AND OBJECTIVES: Radiofrequency ablation has recently been used for the treatment of benign thyroid nodules, with outstanding results. However, in most studies, the procedure was usually performed by a radiologist or surgeon. This study aimed to evaluate the efficacy and safety of radiofrequency ablation for nodules >2 cm performed by an endocrinologist with several years of experience performing fine-needle aspiration cytology. MATERIALS AND METHODS: This study was a cross-sectional analysis of 111 patients who received radiofrequency ablation between April 2010 and July 2013. A total of 73 patients with 75 nodules >2 cm in diameter with at least 6 months of follow-up examinations were included. RESULTS: The mean follow-up period was 11.5 months. The mean nodule volume decreased from 17.0+/-15.3 mL preoperatively to 6.0+/-8.5 mL postoperatively, with a mean volume reduction of 69.7%. There were no major complications, and only 1 patient (1.3%) presented with a minor complication (hemorrhaging of the thyroid parenchyma). CONCLUSION: Radiofrequency ablation is a safe method for reducing benign thyroid nodules, and is not associated with any major complications.