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J Stroke. 2016 Sep;18(3):267-272. English. Review. https://doi.org/10.5853/jos.2016.00206
Zhang Z , Chopp M .
Henry Ford Hospital, Michigan, United States. zhazh@neuro.hfh.edul
Department of Physics, Oakland University, Rochester, Michigan, United States.
Abstract

Stroke activates neural stem cells in the ventricular-subventricular zone (V/SVZ) of the lateral ventricle, which increases neuroblasts and oligodendrocyte progenitor cells (OPCs). Within the ischemic brain, neural stem cells, neuroblasts and OPCs appear to actively communicate with cerebral endothelial cells and other brain parenchymal cells to mediate ischemic brain repair; however, stroke-induced neurogenesis unlikely plays any significant roles in neuronal replacement. In this mini-review, we will discuss recent findings how intercellular communications between stroke-induced neurogenesis and oligodendrogenesis and brain parenchymal cells could potentially facilitate brain repair processes.

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