OBJECTIVES: This study evaluated the effect on bone mineral density (BMD) in postmenopausal invasive cervical cancer patients treated with radical operation and concurrent chemoradiotherapy (CCRT). METHODS: We analyzed the BMD of spinal bone and the femur in 48 invasive cervical cancer patients treated with CCRT after radical operation. All BMD was measured by dual-energy X-ray absorptiometry. For comparison with control women, 96 patients without gynecological disease whose age and body mass index are consistent with the case group were selected. The measurement interval was 1 year. All of the patients and control women had reached their menopause. RESULTS: Age, height, body weight and body mass index were not significantly different between the two groups. The serum levels of calcium and phosphate were not significantly different between the patients with cervical cancer and control women before and after treatment. On the other hands, the concentrations of total alkaline phosphatase and osteocalcin of patients with invasive cervical cancer were significantly lower (P<0.05) than those of control women after treatment. BMD showed inconsistent outcomes, but there is a trend of decrease after operation and CCRT in invasive cervical cancer. CONCLUSIONS: Our study suggests that invasive cervical cancer patients treated with radical operation and CCRT have a lower BMD, resulting in an increased risk of osteoporosis.