Recently, vertebroplasy has been widely used to treat osteoporotic vertebral compression fractures in the elderly. Outstanding results such as immediate pain relief and functional improvement have been achieved using vertebroplasty. However, some elderly patients suffer from multiple osteoporotic compression fractures due to severe osteoporosis. Although treating single- or 2-level osteoporotic spinal compression fractures using vertebroplasty has shown some significant curative effects and results, few reports are available in the management of multiple-level compression fractures. The purpose of this study is to report the cases that brought good clinical results using vertebroplasty to multiple osteoporotic compression fractures, including a review of the relevant literatures.