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Osteoporosis. 2011 Apr;9(1):132-138. Korean. Original Article.
Kim SA , Kim A , Ji YI , Kim HY , Choi JS , Choi WJ , Jung MH , Lee JY , Jung H .
Department of Obstetrics and Gynecology, Medical School, Chosun University, Gwangju, Korea.
Department of Obstetrics and Gynecology, College of Medicine, Wonkwang University, Gunpo, Korea. bimilo@hanmail.net
Department of Obstetrics and Gynecology, Haeundae Paik Hospital, Inje university, Busan, Korea.
Department of Obstetrics and Gynecology, Kosin University, Busan, Korea.
Department of Family Medicine, Kosin University, Busan, Korea.
Department of Obstetrics and Gynecology, School of Medicine, Gyeongsang National University, Jinju, Korea.
Department of Obstetrics and Gynecology, Kyung Hee Medical Center, Kyung Hee University, Seoul, Korea.
Department of Obstetrics and Gynecology, School of Medicine, Konkuk University, Seoul, Korea.
Abstract

OBJECTIVES: To evaluate the effect of postmenopausal hormone therapy alone or in combination with bisphosphonate on bone mineral density (BMD) in postmenopausal women. METHODS: One hundred three women diagnosed with low BMD in postmenopausal women were included in this study. All patients were classified into two groups; oarl hormone therpy alone (Group I) or with alendronate (Group II), given for 12 months. Dual energy X-ray absorptiometry was used to measure BMD before and after 12 months of treatment. RESULTS: In all groups, significant increase in bone density measurements were seen at 12 months of treatment. The BMD of lumbar spine more increased significantly in Group II than Group I. CONCLUSIONS: Postmenopausal hormone therapy is effective in osteopenic and osteoporotic women. However, the combined treatment with hormone therapy and bisphophonate is more effective in postmenopausal women with low BMD.

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