Journal Browser Advanced Search Help
Journal Browser Advanced search HELP
Osteoporosis. 2011 Apr;9(1):126-131. Korean. Original Article.
Oh YL , Choi JS , Jung MH , Lee JY , Ji YI , Jung H , Choi WJ , Kim HY .
Department of Obstetrocs & Gynecology, College of Medicine, Kosin University, Busan, Korea. marianna1113@naver.com
Department of Family Medicine, College of Medicine, Kosin University, Busan, Korea.
Department of Obstetrics and Gynecology, Kyung Hee Medical Center, Kyung Hee University, Seoul, Korea.
Department of Obstetrics and Gynecology, School of Medicine, Konkuk University, Seoul, Korea.
Department of Obstetrics and Gynecology, Haeundae Paik Hospital, Inje university, Busan, Korea.
Department of Obstetrics and Gynecology, College of Medicine, Chosun University, Gwangju, Korea.
Department of Obstetrics and Gynecology, School of Medicine, Gyeongsang National University, Jinju, Korea.
Abstract

OBJECTIVES: To investigate the incidence of non-responder to hormone therapy (HT) and to evaluate the bone response to HT according to basal bone mineral density(BMD) in postmenopausal women. METHODS: A total of 167 postmenopausal women received either continuous combined estrogenprogestogen replacement (n=102) or estrogen replacement (n=65) for 1 years. BMD at the lumbar spine and femoral neck was measured by dual energy X-ray absorptiometry (DXA) before and 1 year after HT. RESULTS: The incidence of non-responder (women with >3% bone loss per year) to HT was 8.3% in the lumbar spine, and 22.1% in femoral neck. non-responder group had a higher basal BMD at the lumbar spine than responder group, and showed bone loss rate of 7.7% per year. After 1 year of HT, postmenopausal women with osteoporosis showed a higher rate of increase in BMD at the lumbar spine and femoral neck than women with normal BMD or osteopenia. CONCLUSIONS: The non-responders to HT have a higher basal lumbar BMD, compared with responders. The higher basal BMD at the lumbar spine is, the less bone conservation effect of HT is.

Copyright © 2019. Korean Association of Medical Journal Editors.