Traditionally, many innovations in digestive surgery were first evaluated using cholecystectomies in humans as an in vivo model. The large number of patients in good condition, the non-reconstructive nature of such an intervention, and the availability of a standardized operative technique for comparison are the main characteristics predisposing gallbladder surgery for assessment of new technologies. The first case of single-port laparoscopic cholecystectomy (SPLC) in the world was reported in 1997 by Navarra and the first case in Korea was reported in 2009. Since then, the use of SPLC has grown rapidly and several randomized controlled trials found that it is safe and feasible compared with conventional laparoscopic cholecystectomy. However, the true advantage of SPLC over conventional surgery remains controversial.