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J Korean Bal Soc. 2008 Jun;7(1):73-76. Korean. Case Report.
Jeong SH , Oh GS , Shin DI , Kim JS .
Department of Neurology, Eulji University School of Medicine, Eulji University Hospital, Daejeon, Korea. mseaj@eulji.ac.kr
Department of Neurology, Chungbuk National University, College of Medicine, Chungbuk National University Hospital, Korea.
Department of Neurology, Seoul National University, College of Medicine, Seoul National University Bundang Hospital, Korea.
Abstract

The binding of anti-GD1b IgG antibody to the cerebellar granular area or spinocerebellar Ia fibers in the peripheral nerves may cause the prominent cerebellar ataxia, mild quadriparesis and sensory dominant neuropathy. A 31-year woman presented with severe cerebellar ataxia and prominent apogeotropic positional nystagmus/vertigo. Increased anti-GD1b antibody IgG in her serum was noted. 18F-flurodeoxyglucose positron emission tomography (FDG-PET) showed decreased uptake in cerebellum. It is the first case of central positional nystagmus with anti-GD1b IgG antibody.

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