Dry eye disease is a disease characterized by ocular irritation symptoms, tear film instability and ocular surface inflammation. Dry eye is due to aqueous tear deficiency or excessive tear evaporation, which causes damage to the ocular surface and is associated with ocular discomforts. A lot of therapy has been developed for treatment and management of dry eye disease. In this article, we review the current therapy for dry eye disease. We present the characteristics and efficacy of therapy for dry eye disease. We believe that our review will aid clinicians in the treatment of patients with dry eye disease.