The work-related psychosocial factor of health professional includes workload, decision latitude, interpersonal conflict, patient factor, job stress, etc. A total of 12,631 employees nationwide, the number of sample being proportional to the Korean Standard Industrial Classification, were diagnosed. Job demand, organization system, lack of reward, and occupational climate were more significant factors for health professionals than other occupations. The psychosocial factor increased the risk of chronic disease (hypertension, coronary heart disease, and musculoskeletal disease) and psychological diseases (alcoholism, depression, anxiety), shift work, specifically, was associated with an increased risk of cancer. It is required that worksite prevention programs be established in occupational as well as individual levels.