Endometriosis is a common, benign, and chronic gynecologic disorder. It is an Estrogen dependent disease that can cause pelvic pain, dysmenorrhea, and infertility. GnRH agonists, Danazol, progestogens, and oral contraceptives have been conventionally used for the medical treatment of endometriosis. Increasing knowledge about endometriosis has introduced more new targeted agents for endometriosis. Further study might be required to evaluate effectiveness and safety of new agents.