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J Korean Soc Biol Psychiatry. 1997 Jun;4(1):48-53. Korean. Original Article.
Kim YM , Lee YS , Lee SH , Oh DY , Yang BH , Cho SS , Nam JH .
Abstract

CV(bDAT) cell line, expressing dopamine transporter stably, has been established by transfection of CV-1 cells with bovine dopamine transporter cDNA. Using CV(bDAT) cells, the effects of various antipsychotic drugs on dopamine uptake were investigated. All of antipsychotic drugs tested, inhibited the [3>H]dopamine uptake into CV(bDAT) cells with IC50s in the low to mid micromolar, implying that antipsychotic drugs may produce overflow of dopamine in the synaptic cleft of dopaminergic neuron.

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