PURPOSE: To investigate the effects of a warm water-filled bag on body temperature, Oxygen demand, respiratory rate and blood sugar in high risk neonates. METHOD: The infants were assigned to two groups, 16 in the experimental and 20 in the control group. Infants in the experimental group was received 40~42 degrees C warm water-filled bag therapy for 2 hours under radiant warmers. Infants in the control group were placed under the same kind of radiant warmers but without the warm water-filled bag. The following were measured every 30 minutes: rectal temperature, O2 demand (FiO2), and respiratory rate. Blood sugar was measured hourly. RESULT: Body temperatures increased significantly in the experimental group (P=0.0138), and there was a difference according to time (P=0.0001). Significant difference were found between the two groups for FiO2 (P=0.0180). There was no difference in respiratory rates between the two groups and rates according to time for the experimental group were also not significant (P=0.3569). No significant difference between two groups was found for blood sugar(P=0.2152), but there was a significant difference according to the times (P=0.0001). CONCLUSION: This results of this study indicate that a warm-filled bag is an effective means of resorting body temperature and reducing O2 demand in high risk neonates.