PURPOSE: The purpose of this study was to identify the effect of hand acupuncture on reduction of headache. METHOD: This study used a quasi-experimental pre-test and post-test design. 45 middle school girls who complained of headache were selected as subjects. The study lasted from November 2002 to June 2003. There were 22 girls in the experimental group while 23 girls were control group; convenience assignment was used. The two groups were homogeneous on characteristics. The experimental group received hand acupuncture. The treatment was to puncture corresponding points (A33, B27, M1, I2) on both the palm and the back of a hand with disposable acupuncture needles, and then remove them after a 20-30 minutes recess during which the subjects reclined on a bed. The data were analyzed using the SPSS PC with Fisher's Exact X(2)-test, and Mann Whitney U-test. RESULT: The results of this study were as follows: 1) In the experimental group, objective pain decreased after hand acupuncture (U= -2.51, p= .01). As for the objective pain degree, a significant reduction in voice change was observed in the experimental groups (U= -2.35, p= .02). Facial expressional changes were observed (U= -1.87, p= .06) and perspiration degree (U= -.99, p= .32) has reduced. However, these differences were not statistically significant between the experimental and control group. 2) Subjective pain degree decreased after hand acupuncture in the experimental as compared to the control group. 3) No statistical significant difference in comfort (U= -.29, p= .78) or distress (U= -1.51, p= .13) between experimental and control group were found. CONCLUSION: These findings indicate that hand acupuncture is an effective method for reducing headache. Therefore, hand acupuncture can be considered as an independent nursing intervention for headache reduction.