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Int Neurourol J. 2014 Sep;18(3):106-114. English. Review.
Fiehn O , Kim J .
West Coast Metabolomics Center, University of California, Davis, Davis, CA, USA.
King Abdulaziz University, Jeddah, Saudi Arabia.
Departments of Surgery and Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Department of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
The Urological Diseases Research Center, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.

Interstitial cystitis (IC), also known as painful bladder syndrome or bladder pain syndrome, is a chronic lower urinary tract syndrome characterized by pelvic pain, urinary urgency, and increased urinary frequency in the absence of bacterial infection or identifiable clinicopathology. IC can lead to long-term adverse effects on the patient's quality of life. Therefore, early diagnosis and better understanding of the mechanisms underlying IC are needed. Metabolomic studies of biofluids have become a powerful method for assessing disease mechanisms and biomarker discovery, which potentially address these important clinical needs. However, limited intensive metabolic profiles have been elucidated in IC. The article is a short review on metabolomic analyses that provide a unique fingerprint of IC with a focus on its use in determining a potential diagnostic biomarker associated with symptoms, a response predictor of therapy, and a prognostic marker.

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