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Infect Chemother. 2010 Aug;42(4):266-270. Korean. Case Report. https://doi.org/10.3947/ic.2010.42.4.266
Kim HW , Choi BS , Kim JH , Shin YM , Lee SJ , Kim SR , Jun JB .
Department of Internal Medicine, University of Ulsan College of Medicine, Ulsan, Korea. uvgotletter@hanmail.net
Department of Laboratory Medicine, University of Ulsan College of Medicine, Ulsan, Korea.
Abstract

Hemophagocytic lymphohistiocytosis (HLH) is a rare disease with a high mortality rate. It is associated with a variety of bacterial, viral, fungal, and parasitic infections. In the literature, there are several cases of HLH associated with scrub typhus in adults, all of which were successfully treated with antibiotic therapy for scrub typhus. This report describes a case of HLH accompanied by scrub typhus in an 81-year-old woman, in whom the disease progressed despite doxycyclin therapy. The patient refused to receive immunosuppressive chemotherapy for HLH and died 5 weeks after admission due to multi-organ failure. To our knowledge, this is the first case of death due to scrub typhus-associated HLH in an adult.

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