LABD is an autoimmune subepidermal bullous disease which is characterized by linear deposition of immunoglobulin (Ig) in the basement membrane. The definite pathogenesis of LABD is still unknown. Some cases of LABD have been associated with drugs. Vancomycin is the most commonly implicated drug. Although LABD is a relatively rare adverse reaction of vancomycin, it is important for clinicians to be aware of this reaction because the use of vancomycin is increasing along with the increase in the incidence of MRSA infections.