BACKGROUND/AIMS: Use of Bernstein test for the diagnosis of GERD has been decreasing gradually over the time, although the test is relatively simple and easy to perform. The aim of this study is to evaluate the diagnostic usefulness of Bernstein test for GERD in comparison with 24-hr esophageal pH monitoring. METHODS: A total of 198 patients (60 men and 138 women; mean age: 53) with non-cardiac chest pain, heartburn or regurgitation were enrolled. They underwent both Bernstein test and 24-hr pH monitoring and the patients who did not have any reflux symptom during 24-hr pH monitoring were excluded. RESULTS: Among 198 patients, 28.3% (56/198) were positive by 24-hr pH monitoring whereas 43.4% (86/198) were positive by Bernstein test Out of eighty six patients with positive Bernstein test, 29 patients (33.7%) present with positive finding also by 24-hr pH monitoring. There was no correlation between Bernstein test and 24-hr pH monitoring in diagnosing for GERD. CONCLUSIONS: Although neither test was superior for making the diagnosis of GERD, Bernstein test could be useful for Asian patients with different clinical features or pathophysiologic mechanisms from western patients.