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Korean J Hematol. 1998 Aug;33(2):198-205. Korean. Original Article.
Han JY , Choi BG , Kim HK , Lee KS .
Department of Internal Medicine, Catholic Cancer Center, College of Medicine, the Catholic University of Korea.
Department of Diagnostic Radiology, Catholic Cancer Center, College of Medicine, the Catholic University of Korea.
Abstract

BACKGROUND: We analyzed retrospectively the clinical features and treatment-related parameters of the aggressive non-Hodgkin's lymphomas (NHL) treated with combination chemotherapy containing doxorubicin to determine the prognostic factors for the response to the treatment and overall survival. METHODS: Adult patients with aggressive NHL who were treated between 1984 to 1993 were evaluated retrospectively for clinical features and treatment-related parameters predictive of the response to the treatment and overall survival, respectively. RESULTS: At 2 years, relapse-free survival and overall survival were 62.2% and 82.6%, respectively, with a median follow-up time of 23.5 months. Significant independent prognostic factors for overall survival were serum LDH level and the complete response (CR) time-interval. For relapse-free survival, the CR time-interval was a significant independent prognostic factor. CONCLUSION: The rapid induction of complete response has a significant implication in the prognosis of aggressive NHL. Appropriate selection of treatment according to the CR time-interval as well as the clinical features of aggressive NHL will improve the overall survival in aggressive NHL.

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