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J Korean Assoc Oral Maxillofac Surg. 2019 Oct;45(5):285-293. English. Original Article.
Arya V , Malhotra VL , Rao JD , Kirti S , Malhotra S , Sharma RS .
Department of Oral and Maxillofacial Surgery, Faculty of Dental Sciences, SGT University, Gurgaon, India.
Department of Dentistry, Shaheed Hasan Khan Mewati (SHKM), Govt. Medical College, Nalhar, Nuh, Mewat, India.
Private Clinic, New Delhi, India.


This study examined the effects of plasma-rich growth factors (PRGF) on accelerating bone regeneration/repair in fresh extraction sockets, and determined the quality and quantity of bone by assessing the bone density using cone-beam computed tomography (CBCT).

Materials and Methods

Twenty patients, who had undergone bilateral extractions, were included in this study. In one extraction socket, PRGF was used and covered with an autologous fibrin plug. Nothing was used in the opposite side extraction socket. Thirteen weeks post extraction, the level of bone regeneration was evaluated on both sides with CBCT.


At the end of the study, the mean bone density according to the Hounsfield units (HU) in the control group and PRGF group was 500.05 HU (type III bone type) and 647.95 HU (type II bone type), respectively.


This study recommends the use of PRGF in post extraction sites to accelerate the rate of bone regeneration and improve the quality of regenerated bone. The technique to process PRGF was simple compared to previously mentioned techniques used for platelet-rich plasma (PRP) preparation. PRP preparation requires a two-cycle centrifugation procedure, leading to a longer processing time.

Copyright © 2019. Korean Association of Medical Journal Editors.