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J Korean Assoc Oral Maxillofac Surg. 2019 Oct;45(5):267-275. English. Original Article. https://doi.org/10.5125/jkaoms.2019.45.5.267
Bhatlawande HC , Kale AD , Desai KM , Hallikerimath S , Belaldavar C , Mane D , Angadi PV , M M , Muttagi S .
Department of Oral Pathology and Microbiology, KLE Academy of Higher Education and Research (KLE University), KLE VK Institute of Dental Sciences and Hospital, Belagavi, India. harshadacb9@gmail.com
Department of Oral and Maxillofacial Surgery, KLE Academy of Higher Education and Research (KLE University), KLE VK Institute of Dental Sciences and Hospital, Belagavi, India.
Abstract

Objectives

Metastasis in oral squamous cell carcinoma (OSCC) can occur in a variety of ways, and draining lymphatics and lymph nodes serve as a common route. Prior to metastasis, lymph nodes elicit an immune response to either wall off or create a favorable environment for homing of tumor cells. This immune response to tumor stimuli is visualized by recognizing various immunoreactive patterns exhibited by the lymph node. The present study aims to evaluate the role of immuno-morphologic patterns of the lymph node in neck dissection for cases of OSCC.

Materials and Methods

Our retrospective study included 50 neck dissection cases of OSCC and a total of 1,078 lymph nodes. The grades of primary tumors with eight different immunoreactive patterns were compared. Vascularity and metastasis in lymph nodes were also evaluated.

Results

The lymphocyte predominant pattern was the most common immunoreactive pattern found in 396 of 1,078 lymph nodes. Patterns of lymphocyte predominant (P=0.0005), sinus histiocytosis (P=0.0500), paracortical hyperplasia (P=0.0001), cortical hyperplasia (P=0.0001), and increased vascularity (P=0.0190) were significantly associated with tumor grade.

Conclusion

The present study adds to the understanding of lymph node immunoreactivity patterns and their correlation with tumor grade. We recommend further study of lymph node patterns for all sentinel lymph node biopsies and routine neck dissections for OSCCs.

Copyright © 2019. Korean Association of Medical Journal Editors.