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J Korean Assoc Oral Maxillofac Surg. 2013 Feb;39(1):9-13. English. Original Article. https://doi.org/10.5125/jkaoms.2013.39.1.9
Lee JK , Kim KW , Choi JY , Moon SY , Kim SG , Kim CH , Kim HM , Kwon YD , Kim YD , Lee DK , Min SK , Park IS , Park YW , Kook MS , Park HJ , Baek JA , Park JW , Kwon TG .
Board of Bone Bank, Ajou University, Suwon, Korea.
Board of Bone Bank, Dankook University, Cheonan, Korea.
Board of Bone Bank, Seoul National University, Seoul, Korea.
Board of Bone Bank, Chosun University, Gwangju, Korea.
Board of Bone Bank, Gachon University Gil Medical Center, Incheon, Korea.
Board of Bone Bank, Kyung Hee University, Seoul, Korea.
Board of Bone Bank, Pusan National University, Yangsan, Korea.
Board of Bone Bank, Daejeon Sun Hospital, Daejeon, Korea.
Board of Bone Bank, Wonkwang University, Iksan, Korea.
Board of Bone Bank, Catholic University of Daegu, Daegu, Korea.
Board of Bone Bank, Gangneung-Wonju National University, Gangneung, Korea.
Board of Bone Bank, Chonnam National University, Gwangju, Korea.
Board of Bone Bank, Chonbuk National University, Jeonju, Korea.
Board of Bone Bank, Hallym University Kangdong Sacred Heart Hospital, Seoul, Korea.
Board of Bone Bank, Kyungpook National University, Daegu, Korea. kwondk@knu.ac.kr
Abstract

OBJECTIVES: Bisphosphonates (BP) are widely used in medicine for inhibiting bone resorption; however bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a major side effect of BP. To date, there have been no specific reports on the incidence of BRONJ among Koreans. This study investigated the preliminary results from a nationwide survey of BRONJ in the Departments of Oral and Maxillofacial Surgery (OMFS) at individual training hospitals. MATERIALS AND METHODS: A total of 15 OMFS departments (10 from dental schools, 4 from medical schools, and 1 from a dental hospital) participated in a multi-centric survey. This study assessed every BRONJ case diagnosed between January 2010 and December 2010. The patient age and BP type were evaluated. RESULTS: A total of 254 BRONJ cases were collected. The majority of BRONJ cases were associated with oral BP therapy, while 21.8% of the cases were associated with intravenous administration. Alendronate was the drug most frequently related to BRONJ (59.2% of cases), followed by risedronate (14.3%) and zolendronate (17.0%). The average age of BRONJ patients was 70.0+/-10.1 years, with a range of 38-88 years of age. With the number of BP patients in Korea reported to be around 600,000 in 2008, the estimated incidence of BRONJ is at least 0.04% or 1 per 2,300 BP patients. CONCLUSION: The results suggest that the estimated incidence of BRONJ in Korea is higher than the incidence of other countries. Future prospective studies should be carried out to investigate the exact epidemiological characteristics of BRONJ in Korea.

Copyright © 2019. Korean Association of Medical Journal Editors.