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Korean Circ J. 2018 Sep;48(9):813-825. English. Multicenter Study. https://doi.org/10.4070/kcj.2017.0340
Rha SW , Choi SH , Kim DI , Jeon DW , Lee JH , Hong KS , Cha TJ , Cho JH , Lee SK , Park YH , Park WJ , Kim HJ , Kim YJ , Lee J , Choi D , .
Division of Cardiology, Department of Internal Medicine, Korea University Guro Hospital, Seoul, Korea.
Division of Cardiology, Department of Internal Medicine, Samsung Medical Center, Seoul, Korea.
Division of Cardiology, Department of Internal Medicine, Inje University Haeundae Paik Hospital, Busan, Korea.
Division of Cardiology, Department of Internal Medicine, National Health Insurance Service Ilsan Hospital, Goyang, Korea.
Division of Cardiology, Department of Internal Medicine, Chungnam National University Hospital, Daejeon, Korea.
Division of Cardiology, Department of Internal Medicine, Hallym University Chuncheon Sacred Heart Hospital, Chuncheon, Korea.
Division of Cardiology, Department of Internal Medicine, Kosin University, Gospel Hospital, Busan, Korea.
Division of Cardiology, Department of Internal Medicine, St. Carollo Hospital, Suncheon, Korea.
Division of Cardiology, Department of Internal Medicine, Ulsan University Hospital, Ulsan, Korea.
Division of Cardiology, Department of Internal Medicine, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Korea.
Division of Cardiology, Department of Internal Medicine, Hallym University Sacred Heart Hospital, Anyang, Korea.
Outcomes Research and Real World Data, Pfizer Pharmaceuticals Korea Ltd., Seoul, Korea.
Department of Biostatistics, Korea University College of Medicine, Seoul, Korea.
Division of Cardiology, Department of Internal Medicine, Severance Cardiovascular Hospital, Yonsei University Health System, Seoul, Korea. CDHLYJ@yuhs.ac
Abstract

Background and Objectives

We aimed to investigate the history of medical resource consumption and quality of life (QoL) in peripheral arterial disease (PAD) patients in Korea.

Methods

This was a prospective, multi-center (23 tertiary-hospitals, division of cardiology), non-interventional study. Adult patients (age ≥20 years) suffering from PAD for the last 12-month were enrolled in the study if they met with any of following; 1) ankle-brachial index (ABI) ≤0.9, 2) lower-extremity artery stenosis on computed tomography angiography ≥50%, or 3) peak-systolic-velocity-ratio (PSVR) on ultrasound ≥2.0. Medical chart review was used to assess patient characteristics/treatment patterns while the history of medical resource consumption and QoL data were collected using a patient survey. QoL was measured using EuroQoL-5-dimensions-3-level (EQ-5D-3L) score system, and the factors associated with QoL were analyzed using multiple linear regression analysis.

Results

This study included 1,260 patients (age: 69.8 years, male: 77.0%). The most prevalent comorbidities were hypertension (74.8%), hyperlipidemia (51.0%) and diabetes-mellitus (50.2%). The 94.1% of the patients took pharmacotherapy including aspirin (76.2%), clopidogrel (53.3%), and cilostazol (33.6%). The 12.6% of the patients were receiving smoking cessation education/pharmacotherapy. A considerable number of patients (500 patients, 40.0%) had visit history to another hospital before diagnosis/treatment at the current hospital, with visits to orthopedic units (50.4%) being the most common. At the time, 29% (or higher) of the patients were already experiencing symptoms of critical limb ischemia. Baseline EQ-5D index and EQ VAS were 0.64±0.24 and 67.49±18.29. Factors significantly associated with QoL were pharmacotherapy (B=0.05053; p=0.044) compared to no pharmacotherapy, and Fontaine stage improvement/maintain stage I (B=0.04448; p < 0.001) compared to deterioration/maintain stage II–IV.

Conclusions

Increase in disease awareness for earlier diagnosis and provision of adequate pharmacotherapy is essential to reduce disease burden and improve QoL of Korean PAD patients.

Copyright © 2019. Korean Association of Medical Journal Editors.