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Korean Circ J. 2016 Jul;46(4):481-489. English. Original Article.
Ahn J , Park SK , Park TS , Kim JH , Yun E , Kim SP , Lee HW , Oh JH , Choi JH , Cha KS , Hong TJ , Lee SY , Lee HC .
Division of Cardiology, Department of Internal Medicine, Pusan National University Hospital, Busan, Korea.
Department of Internal Medicine, Busan Medical Center, Busan, Korea.
Department of Biostatistics, Pusan National University Hospital, Busan, Korea.
Department of Cardiovascular Surgery, Pusan National University Hospital, Busan, Korea.
Family Medicine Clinic and Research Institute of Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Korea.
Medical Education Unit and Medical Research Institute, Pusan National University School of Medicine, Yangsan, Korea.

BACKGROUND AND OBJECTIVES: Statins remain the mainstay of secondary coronary artery disease (CAD) prevention, but n-3 polyunsaturated fatty acids (ω-3 PUFA) display biological effects that may also reduce the risk of atherosclerosis and CAD. However, data on the possible antiatherosclerotic benefits of adding ω-3 PUFA to statin therapy are limited. This study aimed to investigate the potential additive effects of ω-3 PUFA on regression of atherosclerosis in CAD patients receiving statin therapy and stent implantation. SUBJECTS AND METHODS: Seventy-four CAD patients undergoing percutaneous coronary intervention (PCI) with stent implantation were enrolled, prescribed statins, and randomly assigned to two groups: n-3 group (ω-3 PUFA 3 g/day, n=38) or placebo group (placebo, n=36). All patients completed the study follow-up consisting of an intravascular ultrasound at baseline and at 12 months. RESULTS: There was no difference in the baseline characteristics and distribution of other medications. No significant differences were observed in primary endpoints, including changes in atheroma volume index (-12.65% vs. -8.51%, p=0.768) and percent atheroma volume (-4.36% vs. -9.98%, p=0.526), and in secondary endpoints including a change in neointimal volume index (7.84 vs. 4.94 mm3/mm, p=0.087). CONCLUSION: ω-3 PUFA had no definite additional effect on the regression of coronary atherosclerosis when added to statin in CAD patients undergoing PCI.

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