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Korean Circ J. 2011 Dec;41(12):733-743. English. Original Article.
Lee JH , Bae JW , Park JB , Park CG , Youn HJ , Choi DJ , Ahn YK , Shin JH , Rim SJ , Bae JH , Kim DW .
Cardiovascular Center of Chungbuk National University Hospital, Cheongju, Korea.
Division of Medicine/Cardiology, Cheil General Hospital, Kwandong University, College of Medicine, Seoul, Korea.
Cardiovascular Center, Korea University Guro Hospital, Seoul, Korea.
Cardiovascular Center and Cardiology Division, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Cardiovascular Center, Seoul National University Bundang Hospital, Seongnam, Korea.
The Heart Center of Chonnam National University Hospital, Gwangju, Korea.
Department of Cardiology, Ajou University School of Medicine, Suwon, Korea.
Division of Cardiology, Department of Internal Medicine, Yonsei University College Medicine, Seoul, Korea.
Department of Cardiology, Heart Center, College of Medicine, Konyang University, Daejeon, Korea.

BACKGROUND AND OBJECTIVES: Morning hypertension is closely related to target organ damage and cardiovascular events. Little data is available concerning the baseline characteristics and comprehensive blood pressure analysis of hypertensive patients on treatment with morning hypertension. SUBJECTS AND METHODS: We evaluated 1,087 hypertensive patients who had taken stable anti-hypertensive medication at least 6 months. The enrolled patients measured their home blood pressure for 7 days. Baseline characteristics and the laboratory data were analyzed. Morning hypertension was defined as a morning blood pressure > or =135/85 mm Hg and systolic or diastolic blood pressure difference between morning and evening exceeding 10 mm Hg. RESULTS: One hundred seventy three patients with morning hypertension showed a preponderance of males, older patients, alcohol consumers, and greater waist circumference and waist-to-hip ratio despite the same body mass index. Impaired fasting glucose and metabolic syndrome were more prevalent in the patients with morning hypertension. The morning hypertensives took more anti-hypertensive drugs and displayed higher blood pressure in the clinic and at home. CONCLUSION: The worse clinical variables and relatively poorly controlled blood pressure of those with morning hypertension supports a potential relationship of morning hypertension with poor cardiovascular outcome. Morning blood pressure should be monitored at home for the optimal treatment of hypertension.

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