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Korean Circ J. 2005 Mar;35(3):215-220. Korean. Original Article. https://doi.org/10.4070/kcj.2005.35.3.215
Choi JR , Park CM , Hong JA , Bae SJ , Eom SM , Cho EY , Ko YG , Park HY , Jang YS .
BK21 Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea. jangys1212@yumc.yonsei.ac.kr
Cardiovascular Genome Center, Yonsei University College of Medicine, Seoul, Korea.
Department of Biostatistics and Computing, Yonsei University College of Medicine, Seoul, Korea.
Yonsei Cardiovascular Research Institute, Yonsei University College of Medicine, Seoul, Korea.
Division of Cardiology, Yonsei University College of Medicine, Seoul, Korea.
Abstract

BACKGROUND AND OBJECTIVES: Cardiovascular disease (CVD) is a complex multigenic disorder, with significant inheritable elements having important roles relating to environmental factors. Recently, the alpha 2 adrenoceptor (alpha(2)-AR) gene has been reported to be involved in the development of coronary artery disease (CAD). The aim of this study was to investigate the relationships between an insertion/deletion (I/D) in alpha(2B)-AR and CAD in Korean subjects. SUBJECTS AND METHODS: The alpha(2B)-AR I/D polymorphism, which was located in the third intracellular loop of the receptor polypeptide, was examined in 292 patients (M:F=219:73) with CAD and 151 healthy control subjects (M:F=70:81) who visited the Cardiovascular Genome Center in Yonsei Cardiovascular Hospital. RESULTS: In the patient group, 77 men (35.1%) and 26 women (35.6%) had the I/I genotype; 105 men (47.9%) and 39 women (53.4%) a heterozygous genotype and 37 (17.0%) and 8 (11.0%) the D/D genotype. In the controls, 23 men (32.8%) and 29 women (35.8%) had the I/I genotype; 38 (54.3%) and 39 (48.1%) the I/D genotype and 9 (12.9%) and 13 (16.1%) the D/D genotype. There were no differences in the genotype frequencies between the patient and control groups, either in men or women. From a logistical regression analysis, the alpha(2B)-AR genotype was not significantly associated with CAD in our study group. CONCLUSION: The alpha(2B)-AR I/D polymorphism is not a risk factor for CAD in the Korean population.

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