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Korean Circ J. 2005 Dec;35(12):904-909. Korean. Multicenter Study.
Song JK , Song JM , Kim YJ , Kang SJ , Kang DH , Chae SC , Kang HS , Bae JH , Kim KS , Shim WJ , Jeong JW , Park JC , Chang KS , Lee JW , Seong IW , Cho EJ , Youn HJ , Lee SC , Park SW , Ha JW , Lim SJ , Chung N , Kim YJ , Sohn DW .
Division of Cardiology, Asan Medical Center, Seoul, Korea.
Kyungpook University Hospital, Daegu, Korea.
Kyunghee University Hospital, Seoul, Korea.
Keimyung University Hospital, Daegu, Korea.
Korea University Hospital, Seoul, Korea.
Wonkwang University Hospital, Iksan, Korea.
Chonnam National University Hospital, Gwangju, Korea.
Chosun University Hospital, Gwangju, Korea.
Chungnam National University Hospital, Daejeon, Korea.
Catholic University Hospital, Seoul, Korea.
Samsing Medical Center, Seoul, Korea.
Yonsei Medical Center, Seoul, Korea.
Seoul National University, Seoul, Korea.

BACKGROUND AND OBJECTIVES: We sought to characterize the lesion characteristics of mitral valve prolapse (MVP), which is being increasingly recognized as a cause of mitral regurgitation (MR) in Koreans SUBJECTS AND METHODS: 497 Patients with MVP that was diagnosed by echocardiography in 13 university-affiliated hospitals from Jan to Dec 2003 were prospectively enrolled in our study. RESULTS: A total of 497 patients (270 males, 54%) were enrolled and their mean age was 52+/-17 years. Grade 4 MR was present in 272 patients (54.7%); grade 3, 2 and 1 MR as present in 30.2%, 10.7% and 4.2%, respectively. MVP of the anterior and posterior mitral leaflet was present in 170 patients (34.2%) and 223 patients (44.9%), respectively; MVP developed in both leaflets in 104 patients (20.9%). In 37 patients (7.4%), MVP developed in all 6 segments of the mitral leaflet and these patients were younger (37+/-14 versus 54+/-16 years, respectively, p<0.05) and had a lower prevalence of chordae rupture and severe MR compared to the other patients. Among the 266 mitral segments showing prolapse in the 132 patients (26.6%) who underwent transesophageal echocardiography, the posterior medial scallop was the most frequently diseased one (26%), and this was followed by the posterior middle scallop (18%), the medial (17%), lateral (14%) and middle (13%) part of the anterior leaflet, and the posterior lateral scallop (12%). Younger patients with a mean age <45 years showed a lower prevalence of single segment prolapse, hypertension, severe MR and chordae rupture compared to the older patients (p<0.001, each). CONCLUSION: The medial part of both mitral leaflets was the predilection site for the development of MVP in Koreans and the lesion characteristics were different according to the patients' age.

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