BACKGROUND AND OBJECTIVES: This prospective single-center randomized clinical study was designed to evaluate the long-term angiographic and clinical outcomes of elective treatment using the Crossflex (coil stent) as compared with the NIR (tubular stent) in patients with native coronary artery disease. SUBJECTS AND METHODS: 104 patients with 107 de novo discrete coronary stenoses were randomly assigned to the NIR stent (54 coronary stenoses) or the Crossflex stent (53 coronary stenoses). Six-month follow-up angiograms were obtained in 83 patients with 86 lesions (80%). Clinical follow up was available in all patients and the period averaged 23.1+/-5.3 months in the Crossflex group and 23.1+/-6.2 months in the NIR group. RESULTS: Procedural success was measured at 100% in both groups. There were no cases of stent thrombosis in either group. Although a higher loss index and more severe follow-up diameter stenosis occurred in the crossflex group, the angiographic restenosis rate was not significantly different in between the groups.